Penicillin concentrations in serum and cerebrospinal fluid after intramuscular injection of aqueous procaine penicillin 0.6 MU with and without probenecid.
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Penicillin concentrations in serum and cerebrospinal fluid after intramuscular injection of aqueous procaine penicillin 0.6 MU with and without probenecid.
Paired specimens of cerebrospinal fluid and serum were taken from 21 patients to estimate penicillin concentrations two to three hours after the last dose of a course of 14-21 daily intramuscular injections of procaine penicillin 0.6 MU. Of 10 patients treated with procaine penicillin alone, eight had no detectable penicillin and two had sub-treponemicidal concentrations (less than 0.018 mg/l) ...
متن کاملVariations in serum concentrations of penicillin after injections of aqueous procaine penicillin G with and without oral probenecid.
Probenecid by inhibiting the renal excretion of penicillin raises its serum level (Boger, Beatty, Pitts, and Flippin, 1950; Burnell and Kirby, 1951; Meads, Knight, and Izlar, 1951; Frisk, Diding, and Wallmark, 1952), a pharmacological effect of which increasing use has been made in the treatment of gonorrhoea (Hilton, 1959; Jensen, Kvorning, and N0rredam, 1963; Holmes, Johnson, and Floyd, 1967;...
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متن کاملPAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea.
In 1944, when gonorrhoea responded to 100,000 units of crystalline penicillin given in divided doses, Miller, Scott, and Moeller (1944) observed that the gonococcus was cleared from the urethral secretions within 1 to 6 hours. 23 years later, Holmes, Johnson, and Floyd (1967), in the Far East, noted that only one case, a therapeutic failure, out of twenty treated with 2-4 m.u. procaine penicill...
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ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 1984
ISSN: 1368-4973
DOI: 10.1136/sti.60.6.371